Multiple meanings of the title, here are a few: 1) Literally, Desire is the name of the streetcar route that Blanche takes to get to her sister’s house. 2) Symbolically, Blanche has let desire take over her life, losing her self-control by hopping on “a streetcar named desire” and enjoying the ride, though she has no idea where it will take her. 3) The fact that it is a streetcar and not a more upscale mode of transportation indicates that even though Blanche pretends to be cultured and rich, she has sunk to poverty and dependence on others because of her desire.