Welcome to the web site for the research lab headed by Laura Runyen-Janecky, Professor of Biology in the Department of Biology at the University of Richmond. We have a Facebook page is and we have a new instagram account at rj_lab_sodalis on instagram. If you are looking for Laura’s personal web site, click here.
Many bacteria, especially symbiotic bacteria, are exposed to a variety of environments during their lifecycles. These environments may be both inside and outside the host, and particular signals in these environments may activate expression of genes that result in changes that allow the bacterium to cope more effectively with the specific environment. One of the current aims of research in the R-J lab iis to understand how bacteria survive in many distinct environments, including those encountered during the course of interaction with the host, by identifying and characterizing genes that are expressed in each environment. Additionally, our lab has become increasing interested in focusing on a very specialized niche for bacterial life, that of the intracellular environment of a eukaryotic cell. Thus, our primary research aim is to determine the physiological requirements for bacteria to live within eukaryotic cells and the bacterial gene regulation in this environment. We have done this by taking a molecular genetic approach using two facultative intracellular bacterial species. The first is Shigella flexneri, the causative agent of shigellosis, and the second is Sodalis glossinidius, a secondary symbiont of the tsetse fly. All current work in the lab involves Sodalis glossinidius.