Publications at the University of Richmond
15. Taggart, E. L.(+); Wolff, E. J.(+); Yanar, P.; Blobe, J. P.; Shugrue, C. R. Development of an oxazole-based cleavable linker for peptides. Bioorg. Med. Chem. 2024, 102, 117663. Link.
Postdoctoral Publications from Massachusetts Institute of Technology (with Prof. Bradley Pentelute):
14. Tuan, S.; Dieppa-Matos, D.; Zhang, C.; Shugrue, C. R.; Dai, P.; Truex, N.; Zhang, G.; Loas, A.; Pentelute, B. L. A reactive peptide interface for site-selective cysteine bioconjugation. Chem. Commun. 2021, 57, 3227–3230. Link.
13. Pomplun, S. J.(+); Shugrue, C. R.(+); Schmitt, A. M.; Schissel, C. K.; Farquhar, C. E.; Pentelute, B. L. Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release. Angew. Chem. Int. Ed. 2020, 59, 11566–11572. (+ co-first authors). Link.
Graduate Publications from Yale University (with Prof. Scott Miller):
12. Metrano, A. J.; Chinn, A. J.; Shugrue, C. R.; Stone, E. A.; Kim, B.; Miller, S. J. Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms. Chem. Rev. 2020, 120, 11479–11615. Link.
11. Dardir, A. H.; Hazari, N.; Miller, S. J.; Shugrue, C. R. Palladium-Catalyzed Suzuki-Miyaura Reactions of Aspartic Acid Derived Phenyl Esters. Org. Lett. 2019, 21, 5762–5766. Link. Highlighted in: Synfacts 2019, 15, 1324. Link.
10. Shugrue, C. R.; Sculimbrene, B. R.; Jarvo, E. R.; Mercado, B. W.; Miller, S. J. Outer-Sphere Control for Divergent Multicatalysis with Common Catalytic Moieties. J. Org. Chem. 2019, 84, 1664–1672. Link.
9. Featherston, A. L.; Shugrue, C. R.; Mercado, B. Q; Miller, S. J. Phosphothreonine (pThr)–Based Multifunctional Peptide Catalysis for Asymmetric Baeyer–Villiger Oxidations of Cyclobutanones. ACS Catal. 2019, 9, 242–252. Link. Highlighted in: Synfacts 2019, 15, 0303. Link.
8. Shugrue, C. R.; Featherston, A. L.; Lackner, R. M.; Lin, A.; Miller, S. J. Divergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3-Amidocyclohexanones. J. Org. Chem. 2018, 83, 4491–4504. Link.
7. Shugrue, C. R.; Miller, S. J. Applications of Non-Enzymatic Catalysts to the Alteration of Natural Products. Chem. Rev. 2017, 117, 11894–11951. Special Issue: Natural Product Synthesis. Link.
6. Alford, J. A.; Abascal, N. C.; Shugrue, C. R.; Colvin, S. M.; Romney, D. K. Aspartyl Oxidation Catalysts that Dial In Functional Group Selectivity, along with Regio- and Stereoselectivity. ACS Cent. Sci. 2016, 2, 733–739. Link.
5. Shugrue, C. R.; Miller, S. J. Phosphothreonine as a Catalytic Residue in Peptide-Mediated Asymmetric Transfer Hydrogenations of 8-Aminoquinolines. Angew. Chem. Int. Ed. 2015, 54, 11173–11176. Link.
Undergraduate Publications from Holy Cross and UT Austin (with Prof. Brian Linton & Prof. Stephen Martin):
4. Klosowski, D. W.; Hethcox, J. C.; Paull, D. H.; Fang, C.; Donald, J. R.; Shugrue, C. R.; Pansick, A. D.; Martin, S. F. Enantioselective Halolactonization Reactions using a BINOL-derived Bifunctional Catalyst: Methodology, Diversification, and Applications. J. Org. Chem. 2018, 83, 5954–5968. Link. Highlighted in: Synfacts 2018, 14, 0790. Link.
3. Shugrue, C. R.; DeFrancisco, J. R.; Metrano, A. J.; Brink, B. B.; Nomoto, R. S.; Linton, B. R. Detection of Weak Hydrogen Bonding to Fluoro and Nitro Groups in Solution using H/D Exchange. Org. Biomol. Chem. 2016, 14, 2223–2227. Link.
2. Shugrue, C. R.; Mentzen, H. H.; Linton, B. R. A colorful solubility exercise for organic chemistry. J. Chem. Ed. 2014, 92, 135–138. Link. Cover Article. Link.
1. Fang, C.; Paull, D. H.; Hethcox, C. J.; Shugrue, C. R.; Martin, S. F. Enantioselective Iodolactonization of Disubstituted Olefinic Acids Using a Bifunctional Catalyst. Org. Lett. 2012, 14, 6290–6293. Link.
