Journeyman Pictures takes viewers on a tour of Botswana’s Highway #1, nicknamed ‘AIDS Highway,’ and explores the lives of families, doctors, pastors, and communities dealing with the AIDS epidemic along the route. Human movement along the highway, along with high levels of prostitution at truck stops, spreads the disease through the African continent. With limited resources and political interest, it is difficult to educate and provide healthcare for the large number of people affected by AIDS, and the disease continues to spread.