{"id":933,"date":"2023-01-12T11:22:35","date_gmt":"2023-01-12T16:22:35","guid":{"rendered":"https:\/\/blog.richmond.edu\/chem205l\/?page_id=933"},"modified":"2023-04-05T13:55:26","modified_gmt":"2023-04-05T17:55:26","slug":"project-5b-s23","status":"publish","type":"page","link":"https:\/\/blog.richmond.edu\/chem205l\/project-5b-s23\/","title":{"rendered":"Project 5B – S23"},"content":{"rendered":"

Background<\/strong><\/span><\/p>\n

In CHEM 206, you will learn a variety of different reactions. Many of these qualify as condensation reactions, in which two (or more) small molecules (i.e., \u201cmonomers\u201d) combine to form a larger molecule. In the process, a small molecule (usually water) is expelled (Figure 1).<\/p>\n

\"\"

Figure 1. A generic condensation reaction.<\/p><\/div>\n

In this project, you will use the structure determination skills you learned this semester to determine the outcome of a condensation reaction between vanillin and benzocaine in the presence of acetic acid (Figure 2).<\/p>\n

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Figure 2. Project 5B reaction puzzle.<\/p><\/div>\n

Procedure<\/strong><\/span><\/p>\n

1. In a 150 mL beaker, combine 1.50 g vanillin and 1.70 g benzocaine.<\/p>\n

2. Add 0.5 mL glacial acetic acid to the mixture. You may measure this quantity using the markings on the plastic pipettes available in the lab.<\/p>\n

3. Use a microspatula to vigorously mix the components until you obtain a dry yellow powder (~5 minutes).<\/p>\n

4. Transfer the solid<\/a><\/span> product to a 125 mL Erlenmeyer flask.<\/p>\n

5. Recrystallize<\/a><\/span> the solid using a 9:1 isopropanol:hexane solvent mixture.<\/p>\n

6. Collect the recrystallized solid by vacuum filtration<\/a><\/span>.<\/p>\n

7. Perform a second recrystallization to further purify the solid. Collect the product by vacuum filtration and allow it to dry on the funnel for at least 30 minutes.<\/p>\n

8. Determine the product yield and characterize it by melting point analysis, GC-MS, IR, and NMR.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background In CHEM 206, you will learn a variety of different reactions. Many of these qualify as condensation reactions, in which two (or more) small molecules (i.e., \u201cmonomers\u201d) combine to form a larger molecule. In the process, a small molecule … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":5206,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"coauthors":[175315],"class_list":["post-933","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/pages\/933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/users\/5206"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/comments?post=933"}],"version-history":[{"count":3,"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/pages\/933\/revisions"}],"predecessor-version":[{"id":964,"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/pages\/933\/revisions\/964"}],"wp:attachment":[{"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/media?parent=933"}],"wp:term":[{"taxonomy":"author","embeddable":true,"href":"https:\/\/blog.richmond.edu\/chem205l\/wp-json\/wp\/v2\/coauthors?post=933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}